| dc.contributor.author |
Magrioti, V |
en |
| dc.contributor.author |
Hadjipavlou-Litina, D |
en |
| dc.contributor.author |
Constantinou-Kokotou, V |
en |
| dc.date.accessioned |
2014-06-06T06:45:37Z |
|
| dc.date.available |
2014-06-06T06:45:37Z |
|
| dc.date.issued |
2003 |
en |
| dc.identifier.issn |
0960894X |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1016/S0960-894X(02)00939-3 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/2541 |
|
| dc.subject.other |
1 o dodecyl 2 deoxy 2 aminoglycerol |
en |
| dc.subject.other |
aminoalcohol |
en |
| dc.subject.other |
antiinflammatory agent |
en |
| dc.subject.other |
carrageenan |
en |
| dc.subject.other |
oleic acid |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
alcohol oxidation |
en |
| dc.subject.other |
animal experiment |
en |
| dc.subject.other |
animal model |
en |
| dc.subject.other |
antiinflammatory activity |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
controlled study |
en |
| dc.subject.other |
dose response |
en |
| dc.subject.other |
drug synthesis |
en |
| dc.subject.other |
esterification |
en |
| dc.subject.other |
female |
en |
| dc.subject.other |
nonhuman |
en |
| dc.subject.other |
paw edema |
en |
| dc.subject.other |
rat |
en |
| dc.subject.other |
reduction |
en |
| dc.subject.other |
Wittig reaction |
en |
| dc.subject.other |
Amino Alcohols |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Anti-Inflammatory Agents, Non-Steroidal |
en |
| dc.subject.other |
Carrageenan |
en |
| dc.subject.other |
Edema |
en |
| dc.subject.other |
Female |
en |
| dc.subject.other |
Indicators and Reagents |
en |
| dc.subject.other |
Oxidation-Reduction |
en |
| dc.subject.other |
Pain Measurement |
en |
| dc.subject.other |
Rats |
en |
| dc.subject.other |
Rats, Inbred F344 |
en |
| dc.title |
Synthesis and in vivo anti-inflammatory activity of long-chain 2-amino-alcohols |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1016/S0960-894X(02)00939-3 |
en |
| heal.publicationDate |
2003 |
en |
| heal.abstract |
The synthesis of optically pure long-chain 2-amino-alcohols and 1-O-dodecyl-2-deoxy-2-amino-sn-glycerol was carried out starting from L- or D-Boc-Ser(OBn)-ol by oxidation and consecutive Wittig reaction or etherification reaction. 2-Amino-oleyl alcohol was synthesized by reduction of the corresponding 2-amino-oleic acid. All the long chain amino-alcohols presented interesting inhibition of carrageenin-induced paw edema in rats (ED50 from 0.017 to 0.010 mmol/kg). © 2002 Elsevier Science Ltd. All rights reserved. |
en |
| heal.journalName |
Bioorganic and Medicinal Chemistry Letters |
en |
| dc.identifier.issue |
3 |
en |
| dc.identifier.volume |
13 |
en |
| dc.identifier.doi |
10.1016/S0960-894X(02)00939-3 |
en |
| dc.identifier.spage |
375 |
en |
| dc.identifier.epage |
377 |
en |