Antimicrobial Activity of Essential Oil and Methanol Extracts of Achillea sintenisii Hub. Mor. (Asteraceae)

dc.contributor.author	Sokmen, A	en
dc.contributor.author	Vardar-Unlu, G	en
dc.contributor.author	Polissiou, M	en
dc.contributor.author	Daferera, D	en
dc.contributor.author	Sokmen, M	en
dc.contributor.author	Donmez, E	en
dc.date.accessioned	2014-06-06T06:45:26Z
dc.date.available	2014-06-06T06:45:26Z
dc.date.issued	2003	en
dc.identifier.issn	0951418X	en
dc.identifier.uri	http://dx.doi.org/10.1002/ptr.1274	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/2440
dc.subject	Achillea sintenisii	en
dc.subject	Antimicrobial activity	en
dc.subject	Camphor	en
dc.subject	Essential oil	en
dc.subject	Eucalyptol	en
dc.subject.other	alpha cubebene	en
dc.subject.other	amikacin	en
dc.subject.other	beta pinene	en
dc.subject.other	borneol	en
dc.subject.other	camphene	en
dc.subject.other	camphor	en
dc.subject.other	caryophyllene	en
dc.subject.other	cineole	en
dc.subject.other	ciprofloxacin	en
dc.subject.other	clindamycin	en
dc.subject.other	essential oil	en
dc.subject.other	methanol	en
dc.subject.other	pinene	en
dc.subject.other	piperitone	en
dc.subject.other	plant extract	en
dc.subject.other	sesquiterpene	en
dc.subject.other	terpene	en
dc.subject.other	unclassified drug	en
dc.subject.other	Achillea	en
dc.subject.other	Achillea sintenisii	en
dc.subject.other	antimicrobial activity	en
dc.subject.other	article	en
dc.subject.other	Asteraceae	en
dc.subject.other	bacterial strain	en
dc.subject.other	bacterium	en
dc.subject.other	Candida albicans	en
dc.subject.other	Candida krusei	en
dc.subject.other	Clostridium perfringens	en
dc.subject.other	controlled study	en
dc.subject.other	distillation	en
dc.subject.other	drug determination	en
dc.subject.other	drug identification	en
dc.subject.other	fractionation	en
dc.subject.other	gas chromatography	en
dc.subject.other	mass spectrometry	en
dc.subject.other	minimum inhibitory concentration	en
dc.subject.other	nonhuman	en
dc.subject.other	yeast	en
dc.subject.other	Achillea	en
dc.subject.other	Anti-Infective Agents	en
dc.subject.other	Candida	en
dc.subject.other	Gas Chromatography-Mass Spectrometry	en
dc.subject.other	Gram-Negative Bacteria	en
dc.subject.other	Gram-Positive Bacteria	en
dc.subject.other	Humans	en
dc.subject.other	Microbial Sensitivity Tests	en
dc.subject.other	Phytotherapy	en
dc.subject.other	Plant Extracts	en
dc.subject.other	Plant Oils	en
dc.subject.other	Achillea	en
dc.subject.other	Asteraceae	en
dc.subject.other	Candida	en
dc.subject.other	Candida albicans	en
dc.subject.other	Clostridium	en
dc.subject.other	Clostridium perfringens	en
dc.subject.other	Dryobalanops	en
dc.title	Antimicrobial Activity of Essential Oil and Methanol Extracts of Achillea sintenisii Hub. Mor. (Asteraceae)	en
heal.type	journalArticle	en
heal.identifier.primary	10.1002/ptr.1274	en
heal.publicationDate	2003	en
heal.abstract	The essential oil, obtained by Clevenger distillation, and water-soluble and water-insoluble parts of the methanol extracts of Achillea sintenisii Hub. Mor. were individually assayed for their antimicrobial activities against 12 bacteria and two yeasts, Candida albicans and C. krusei. No activity was exhibited by the water-soluble subfraction, whereas both the water-insoluble subfraction of the methanol extracts and the essential oil were found to be active against some test microorganisms studied. Since the essential oil possessed stronger activity than the other extracts tested, it was further fractionated and the fractions were evaluated for their antimicrobial activity, followed by GC-MS analysis, resulting in the identification of 32 compounds which constituted 90.2% of the total oil. The GC-MS analysis of the oil and its fractions revealed that the main components of the oil, e.g. camphor and eucalyptol, possessed appreciable activity against C. albicans and Clostridium perfringens. The findings presented here also suggest that the other constituents of the oil, e.g. borneol and piperitone can also be taken into account for the activity observed. Copyright © 2003 John Wiley & Sons, Ltd.	en
heal.journalName	Phytotherapy Research	en
dc.identifier.issue	9	en
dc.identifier.volume	17	en
dc.identifier.doi	10.1002/ptr.1274	en
dc.identifier.spage	1005	en
dc.identifier.epage	1010	en