| dc.contributor.author |
Couladouros, EA |
en |
| dc.contributor.author |
Strongilos, AT |
en |
| dc.date.accessioned |
2014-06-06T06:45:03Z |
|
| dc.date.available |
2014-06-06T06:45:03Z |
|
| dc.date.issued |
2002 |
en |
| dc.identifier.issn |
14337851 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1002/1521-3773(20021004)41:19<3677::AID-ANIE3677>3.0.CO;2-Y |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/2225 |
|
| dc.subject |
Combinatorial chemistry |
en |
| dc.subject |
Drug design |
en |
| dc.subject |
Heterocycles |
en |
| dc.subject |
Solid-phase synthesis |
en |
| dc.subject.other |
Drug products |
en |
| dc.subject.other |
Organic compounds |
en |
| dc.subject.other |
Pharmacophoric structures |
en |
| dc.subject.other |
Herbicides |
en |
| dc.subject.other |
aclacinomycin |
en |
| dc.subject.other |
actinobolin |
en |
| dc.subject.other |
antibiotic agent |
en |
| dc.subject.other |
antifungal agent |
en |
| dc.subject.other |
antiinfective agent |
en |
| dc.subject.other |
antineoplastic agent |
en |
| dc.subject.other |
asperlin |
en |
| dc.subject.other |
benzodiazepine derivative |
en |
| dc.subject.other |
butenolide |
en |
| dc.subject.other |
coccidiostatic agent |
en |
| dc.subject.other |
forskolin |
en |
| dc.subject.other |
frontalin |
en |
| dc.subject.other |
herbicide |
en |
| dc.subject.other |
lactone derivative |
en |
| dc.subject.other |
macrolide |
en |
| dc.subject.other |
monocrotaline |
en |
| dc.subject.other |
nogalamycin |
en |
| dc.subject.other |
oxazole derivative |
en |
| dc.subject.other |
penicillic acid |
en |
| dc.subject.other |
pesticide |
en |
| dc.subject.other |
pseudomonic acid |
en |
| dc.subject.other |
pyranoside |
en |
| dc.subject.other |
pyrone derivative |
en |
| dc.subject.other |
spironolactone |
en |
| dc.subject.other |
steroid |
en |
| dc.subject.other |
thiazepine derivative |
en |
| dc.subject.other |
tirandamycin |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
binding site |
en |
| dc.subject.other |
chemical structure |
en |
| dc.subject.other |
chemistry |
en |
| dc.subject.other |
combinatorial chemistry |
en |
| dc.subject.other |
complex formation |
en |
| dc.subject.other |
directed molecular evolution |
en |
| dc.subject.other |
drug design |
en |
| dc.subject.other |
drug structure |
en |
| dc.subject.other |
genetic polymorphism |
en |
| dc.subject.other |
methodology |
en |
| dc.subject.other |
pharmacophore |
en |
| dc.subject.other |
structure activity relation |
en |
| dc.subject.other |
Binding Sites |
en |
| dc.subject.other |
Combinatorial Chemistry Techniques |
en |
| dc.subject.other |
Directed Molecular Evolution |
en |
| dc.subject.other |
Drug Design |
en |
| dc.subject.other |
Molecular Structure |
en |
| dc.subject.other |
Pyrones |
en |
| dc.subject.other |
Structure-Activity Relationship |
en |
| dc.title |
Generation of libraries of pharmacophoric structures with increased complexity and diversity by employing polymorphic scaffolds |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1002/1521-3773(20021004)41:19<3677::AID-ANIE3677>3.0.CO;2-Y |
en |
| heal.publicationDate |
2002 |
en |
| heal.abstract |
Antimicrobials, antifungals, anticoccidials, pesticides, and herbicides - druglike scaffolds with potential applications such as these are provided by a combinatorial library containing oxazolediones, naphthoquinones, thiazinones, and diazepinones which were obtained within a few simple steps from solid-supported 2H-pyran-3(6H)-ones as ""polymorphic"" key intermediate leads (see scheme). |
en |
| heal.journalName |
Angewandte Chemie - International Edition |
en |
| dc.identifier.issue |
19 |
en |
| dc.identifier.volume |
41 |
en |
| dc.identifier.doi |
10.1002/1521-3773(20021004)41:19<3677::AID-ANIE3677>3.0.CO;2-Y |
en |
| dc.identifier.spage |
3677 |
en |
| dc.identifier.epage |
3680 |
en |