| dc.contributor.author |
Singh, J |
en |
| dc.contributor.author |
Vlijmen, H |
en |
| dc.contributor.author |
Lee, W |
en |
| dc.contributor.author |
Liao, Y |
en |
| dc.contributor.author |
Lin, K |
en |
| dc.contributor.author |
Ateeq, H |
en |
| dc.contributor.author |
Cuervo, J |
en |
| dc.contributor.author |
Zimmerman, C |
en |
| dc.contributor.author |
Hammond, C |
en |
| dc.contributor.author |
Karpusas, M |
en |
| dc.contributor.author |
Palmer, R |
en |
| dc.contributor.author |
Chattopadhyay, T |
en |
| dc.contributor.author |
Adams, S |
en |
| dc.date.accessioned |
2014-06-06T06:44:53Z |
|
| dc.date.available |
2014-06-06T06:44:53Z |
|
| dc.date.issued |
2002 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1023/A:1020130418084 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/2120 |
|
| dc.subject |
Cross Validation |
en |
| dc.subject |
Model Coupling |
en |
| dc.subject |
Multiple Sclerosis |
en |
| dc.subject |
Prediction Model |
en |
| dc.subject |
Structure Activity Relationship |
en |
| dc.subject |
X Rays |
en |
| dc.subject |
N Terminal |
en |
| dc.subject |
White Blood Cell |
en |
| dc.title |
3D QSAR (COMFA) of a series of potent and highly selective VLA4 antagonists |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1023/A:1020130418084 |
en |
| heal.publicationDate |
2002 |
en |
| heal.abstract |
The integrin VLA-4 (a4ß1) is involved in the migration of white blood cells to sites of inflammation, and is implicated in the pathology of a variety of diseases including asthma and multiple sclerosis. We report the structure-activity relationships of a series of VLA-4 antagonists that were based upon the integrin-binding sequence of the connecting segment peptide of fibronectin (Leu-Asp-Val), and |
en |
| heal.journalName |
Journal of Computer-aided Molecular Design |
en |
| dc.identifier.doi |
10.1023/A:1020130418084 |
en |