| dc.contributor.author |
Mylonas, S |
en |
| dc.contributor.author |
Valavanidis, A |
en |
| dc.contributor.author |
Dimitropoulos, K |
en |
| dc.contributor.author |
Polissiou, M |
en |
| dc.contributor.author |
Tsiftsoglou, AS |
en |
| dc.contributor.author |
Vizirianakis, IS |
en |
| dc.date.accessioned |
2014-06-06T06:41:42Z |
|
| dc.date.available |
2014-06-06T06:41:42Z |
|
| dc.date.issued |
1988 |
en |
| dc.identifier.issn |
01620134 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/208 |
|
| dc.relation.uri |
http://www.scopus.com/inward/record.url?eid=2-s2.0-0024243861&partnerID=40&md5=96b7a5cd8c8e4c9b7763ce4abec22726 |
en |
| dc.subject.other |
benzimidazole derivative |
en |
| dc.subject.other |
cisplatin |
en |
| dc.subject.other |
palladium complex |
en |
| dc.subject.other |
platinum complex |
en |
| dc.subject.other |
antineoplastic activity |
en |
| dc.subject.other |
cell culture |
en |
| dc.subject.other |
complex formation |
en |
| dc.subject.other |
drug structure |
en |
| dc.subject.other |
drug synthesis |
en |
| dc.subject.other |
proton nuclear magnetic resonance |
en |
| dc.subject.other |
Animal |
en |
| dc.subject.other |
Antineoplastic Agents |
en |
| dc.subject.other |
Benzimidazoles |
en |
| dc.subject.other |
Cell Survival |
en |
| dc.subject.other |
Drug Evaluation, Preclinical |
en |
| dc.subject.other |
Human |
en |
| dc.subject.other |
Magnetic Resonance Spectroscopy |
en |
| dc.subject.other |
Neoplasms, Experimental |
en |
| dc.subject.other |
Palladium |
en |
| dc.subject.other |
Platinum |
en |
| dc.subject.other |
Spectrophotometry, Infrared |
en |
| dc.subject.other |
Tumor Cells, Cultured |
en |
| dc.title |
Synthesis, molecular structure determination, and antitumor activity of platinum(II) and palladium(II) complexes of 2-substituted benzimidazole |
en |
| heal.type |
journalArticle |
en |
| heal.publicationDate |
1988 |
en |
| heal.abstract |
The complexes of 2-aminomethyl benzimidazole, 2-(β-aminoethyl)benzimidazole, and 2-(α-aminoethyl)benzimidazole with Pt(II) and Pd(II) have been prepared. The molecular structure of the free ligands and their complexes were studied by IR and 1H NMR. It was concluded that the substituted benzimidazole derivatives behave as bidentate ligands, being bound to the metal atoms via the nitrogen of the -N = group and the amino group of the side chain of the benzimidazole ring. The metal complexes were tested for antineoplastic activity both in cultures of neoplastic cells (MEL-745, K-562, Colon 205, IMP-32, SK-N-SH) and in vivo in rodents bearing L-1210 leukemia. The antiproliferative activity of these agents was compared to that of cis-platin. © 1988. |
en |
| heal.journalName |
Journal of Inorganic Biochemistry |
en |
| dc.identifier.issue |
4 |
en |
| dc.identifier.volume |
34 |
en |
| dc.identifier.spage |
265 |
en |
| dc.identifier.epage |
275 |
en |