| dc.contributor.author |
Kasiotis, KM |
en |
| dc.contributor.author |
Magiatis, P |
en |
| dc.contributor.author |
Pratsinis, H |
en |
| dc.contributor.author |
Skaltsounis, AL |
en |
| dc.contributor.author |
Abadji, V |
en |
| dc.contributor.author |
Charalambous, A |
en |
| dc.contributor.author |
Moutsatsou, P |
en |
| dc.contributor.author |
Haroutounian, SA |
en |
| dc.date.accessioned |
2014-06-06T06:44:46Z |
|
| dc.date.available |
2014-06-06T06:44:46Z |
|
| dc.date.issued |
2001 |
en |
| dc.identifier.issn |
0039-128X |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/2062 |
|
| dc.subject |
daunorubicin conjugates |
en |
| dc.subject |
steroidal and non-steroidal estrogen ligand |
en |
| dc.subject |
synthesis |
en |
| dc.subject |
estrogen receptor binding |
en |
| dc.subject |
cytotoxic activity |
en |
| dc.subject.classification |
Biochemistry & Molecular Biology |
en |
| dc.subject.classification |
Endocrinology & Metabolism |
en |
| dc.subject.other |
CYTO-TOXIC AGENTS |
en |
| dc.subject.other |
BINDING-AFFINITY |
en |
| dc.subject.other |
CELL-LINE |
en |
| dc.subject.other |
RECEPTOR |
en |
| dc.subject.other |
COMPLEXES |
en |
| dc.subject.other |
GROWTH |
en |
| dc.title |
Synthesis and biological evaluation of novel daunorubicin-estrogen conjugates |
en |
| heal.type |
journalArticle |
en |
| heal.language |
English |
en |
| heal.publicationDate |
2001 |
en |
| heal.abstract |
The synthesis of two novel daunorubicin-estro-en conjugates with a steroidal and a non-steroidal ligand was undertaken in an attempt to target the cytotoxicity of anthracycline to estrogen-receptor positive cells. These conjugates (3 and 4), in contrast to their corresponding ligands, displayed weak binding affinities of 0.079 and 0.851 for the estrogen receptor. Conjugate 3 was consistently more cytotoxic than 4, which however showed some selectivity to estrogen receptor positive cell lines. (C) 2001 Elsevier Science Inc. All rights reserved. |
en |
| heal.publisher |
ELSEVIER SCIENCE INC |
en |
| heal.journalName |
STEROIDS |
en |
| dc.identifier.issue |
10 |
en |
| dc.identifier.volume |
66 |
en |
| dc.identifier.isi |
ISI:000171150600009 |
en |
| dc.identifier.spage |
785 |
en |
| dc.identifier.epage |
791 |
en |