Rapid quantitative determination of ciprofloxacin in pharmaceuticals by use of solid-state FT-Raman spectroscopy

dc.contributor.author	Skoulika, SG	en
dc.contributor.author	Georgiou, CA	en
dc.date.accessioned	2014-06-06T06:44:42Z
dc.date.available	2014-06-06T06:44:42Z
dc.date.issued	2001	en
dc.identifier.issn	00037028	en
dc.identifier.uri	http://dx.doi.org/10.1366/0003702011953298	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/2023
dc.subject	Ciprofloxacin	en
dc.subject	Determination	en
dc.subject	FT-Raman	en
dc.subject	Pharmaceuticals	en
dc.subject	Quantitative	en
dc.subject	Solids	en
dc.subject.other	Chemical analysis	en
dc.subject.other	Correlation methods	en
dc.subject.other	Drug dosage	en
dc.subject.other	Fourier transform infrared spectroscopy	en
dc.subject.other	Raman spectroscopy	en
dc.subject.other	Relative standard deviation (RSD)	en
dc.subject.other	Drug products	en
dc.title	Rapid quantitative determination of ciprofloxacin in pharmaceuticals by use of solid-state FT-Raman spectroscopy	en
heal.type	journalArticle	en
heal.identifier.primary	10.1366/0003702011953298	en
heal.publicationDate	2001	en
heal.abstract	FT-Raman spectroscopy based on band intensity or band area measurements was used for the quantitative determination of ciprofloxacin in pharmaceutical solid dosage forms. Univariate calibration was used for quantitative analysis. Bands observed at 1708, 1624, 1548, 1493, 1273, 1253, 1238, 1024, 805, 787, 752, 718, 665, and 638 cm-1 were used. Calibration curves were linear in the concentration range of 3-100% w/w with correlation coefficients of 0.99-0.996 and 0.991-0.9993 for band intensity and band area measurements, respectively. Precision ranged from 0-11 and 0.4-12% relative standard deviation (RSD) (n = 3) for band intensity and band area measurements, respectively, and results were in good agreement with the results obtained by the current United States Pharmacopoeia (USP 24) and National Formulary (NF 19) method. Multivariate calibration was also used for quantitative analysis. Multiple linear regression using the intensities of the 1545 and 1272 cm-1 bands gave results in accordance with those obtained by the current United States Pharmacopoeia (USP 24) and National Formulary (NF 19) method. As measurement takes just 30 s using the analytical readout from a single band, the proposed method can be used to replace tedious and time-consuming methods.	en
heal.journalName	Applied Spectroscopy	en
dc.identifier.issue	9	en
dc.identifier.volume	55	en
dc.identifier.doi	10.1366/0003702011953298	en
dc.identifier.spage	1259	en
dc.identifier.epage	1265	en