| dc.contributor.author |
Koulocheri, SD |
en |
| dc.contributor.author |
Haroutounian, SA |
en |
| dc.date.accessioned |
2014-06-06T06:44:27Z |
|
| dc.date.available |
2014-06-06T06:44:27Z |
|
| dc.date.issued |
2001 |
en |
| dc.identifier.issn |
1434193X |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/1888 |
|
| dc.relation.uri |
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035034612&partnerID=40&md5=41d53c3f222eb69a573827f213c35e29 |
en |
| dc.subject |
Cyclization |
en |
| dc.subject |
Estrogen receptor |
en |
| dc.subject |
Indoles |
en |
| dc.subject |
Ultrasound |
en |
| dc.subject.other |
2,3 bis(4 hydroxyphenyl)indole |
en |
| dc.subject.other |
estrogen receptor |
en |
| dc.subject.other |
indole derivative |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
binding site |
en |
| dc.subject.other |
derivatization |
en |
| dc.subject.other |
drug isolation |
en |
| dc.subject.other |
flow cytometry |
en |
| dc.subject.other |
ligand binding |
en |
| dc.subject.other |
receptor binding |
en |
| dc.subject.other |
structure analysis |
en |
| dc.subject.other |
synthesis |
en |
| dc.subject.other |
ultrasound |
en |
| dc.title |
Ultrasound-promoted synthesis of 2,3-bis(4-hydroxyphenyl)indole derivatives as inherently fluorescent ligands for the estrogen receptor |
en |
| heal.type |
journalArticle |
en |
| heal.publicationDate |
2001 |
en |
| heal.abstract |
A series of 2,3-bis(4-hydroxyphenyl)indole derivatives 4c-f was prepared by ultrasound-promoted intramolecular cyclodehydration of a polyphosphoric acid solution of α-anilinyl-(or 3-anisidyl)desoxyanisoins 2c-f, and their optical spectroscopy and estrogen receptor (ER) binding properties were studied. Compounds 4c-f give intense long-wavelength fluorescent emission, sensitive to solvent polarity and pH. Furthermore, the two indol-6-ols 4e, f display reasonably good binding affinities to ER and appear to be well suited for use as fluorescent probes for the detection of ER in cells. |
en |
| heal.journalName |
European Journal of Organic Chemistry |
en |
| dc.identifier.issue |
9 |
en |
| dc.identifier.spage |
1723 |
en |
| dc.identifier.epage |
1729 |
en |