A longitudinal investigation of aggregate oral intake of copper

dc.contributor.author	Pang, Y	en
dc.contributor.author	MacIntosh, DL	en
dc.contributor.author	Ryan, PB	en
dc.date.accessioned	2014-06-06T06:44:24Z
dc.date.available	2014-06-06T06:44:24Z
dc.date.issued	2001	en
dc.identifier.issn	00223166	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/1858
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0034894845&partnerID=40&md5=d95433238bf440bef91ce7c2b0a8f838	en
dc.subject	Aggregate daily intake	en
dc.subject	Copper	en
dc.subject	Humans	en
dc.subject	Longitudinal	en
dc.subject	Reliability	en
dc.subject	Temporal variation	en
dc.subject.other	copper	en
dc.subject.other	drinking water	en
dc.subject.other	adolescent	en
dc.subject.other	adult	en
dc.subject.other	aged	en
dc.subject.other	article	en
dc.subject.other	beverage	en
dc.subject.other	copper blood level	en
dc.subject.other	copper deficiency	en
dc.subject.other	copper metabolism	en
dc.subject.other	female	en
dc.subject.other	food	en
dc.subject.other	food contamination	en
dc.subject.other	high risk population	en
dc.subject.other	human	en
dc.subject.other	longitudinal study	en
dc.subject.other	major clinical study	en
dc.subject.other	male	en
dc.subject.other	mass spectrometry	en
dc.subject.other	measurement	en
dc.subject.other	population research	en
dc.subject.other	reliability	en
dc.subject.other	statistical analysis	en
dc.subject.other	Administration, Oral	en
dc.subject.other	Adolescent	en
dc.subject.other	Adult	en
dc.subject.other	Aged	en
dc.subject.other	Aged, 80 and over	en
dc.subject.other	Beverages	en
dc.subject.other	Copper	en
dc.subject.other	Drinking	en
dc.subject.other	Eating	en
dc.subject.other	Environmental Exposure	en
dc.subject.other	Female	en
dc.subject.other	Food Analysis	en
dc.subject.other	Humans	en
dc.subject.other	Longitudinal Studies	en
dc.subject.other	Male	en
dc.subject.other	Mass Spectrometry	en
dc.subject.other	Middle Aged	en
dc.subject.other	Nutrition Assessment	en
dc.subject.other	Nutrition Surveys	en
dc.subject.other	Water Supply	en
dc.title	A longitudinal investigation of aggregate oral intake of copper	en
heal.type	journalArticle	en
heal.publicationDate	2001	en
heal.abstract	Four-day composite solid food and beverage duplicate plates and 1-L samples of drinking water were collected from a stratified random sample of 80 individuals as part of the National Human Exposure Assessment Survey in Maryland. The media were obtained from each participant in up to six equally spaced sampling cycles over a year and analyzed for copper by inductively coupled plasma mass spectrometry. Copper concentrations (μg/kg) and consumption rates (kg/d) of solid food, beverage and drinking water were used to derive average daily aggregate oral intake of copper (μg/d). The mean aggregate copper intake of 263 measurements obtained from 68 people was 923.2 ± 685.6 μg/d (mean ± SD). Intake through solid food accounted for the majority of aggregate daily intake of copper contributing 87% on average. According to results from mixed model analysis of variance procedures, the mean log-transformed average daily copper intake in each medium except beverage exhibited significant (P < 0.05) variability among sampling cycles. Between-person variability accounted for 50% of the total variance in aggregate copper intake. As measured by the coefficient of variation, distributions of copper intake consisting of one observation per individual were more variable than the distribution consisting of the long-term average intake for each person. These results suggest that estimates of the fraction of a population at risk from chronic copper deficiency or excess copper intake can be overestimated if based upon short-term measures of copper intake. In addition, these results indicate that longitudinal information is required for accurate assessment of aggregate oral intake of copper for an individual.	en
heal.journalName	Journal of Nutrition	en
dc.identifier.issue	8	en
dc.identifier.volume	131	en
dc.identifier.spage	2171	en
dc.identifier.epage	2176	en