| dc.contributor.author |
Chiou, A |
en |
| dc.contributor.author |
Markidis, T |
en |
| dc.contributor.author |
Constantinou-Kokotou, V |
en |
| dc.contributor.author |
Verger, R |
en |
| dc.contributor.author |
Kokotos, G |
en |
| dc.date.accessioned |
2014-06-06T06:44:22Z |
|
| dc.date.available |
2014-06-06T06:44:22Z |
|
| dc.date.issued |
2000 |
en |
| dc.identifier.issn |
15237060 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/1836 |
|
| dc.relation.uri |
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034628223&partnerID=40&md5=404e2b85a3b13c9633c1fa228056c7c1 |
en |
| dc.title |
Synthesis and study of a lipophilicα-keto amide inhibitor of pancreatic lipase |
en |
| heal.type |
journalArticle |
en |
| heal.publicationDate |
2000 |
en |
| heal.abstract |
(Matrix presented) A lipophilic α-keto amide, inhibitor of pancreatic lipase, was synthesized using a lipidic 2-amino alcohol as backbone. The chiral key intermediate 2-(tert-butyloxycarbonylamino)-D-undecen-5-ol was synthesized starting from D-glutamic acid. The inhibitor formed a stable monomolecular film at the air/water interface as shown by a force/area curve. Inhibition studies using the monomolecular film technique with mixed films of 1,2-dicaprin containing variable proportions of the inhibitor showed a 50% decrease in lipase activity at a 0.14 molar fraction. |
en |
| heal.journalName |
Organic Letters |
en |
| dc.identifier.issue |
3 |
en |
| dc.identifier.volume |
2 |
en |
| dc.identifier.spage |
347 |
en |
| dc.identifier.epage |
350 |
en |