| dc.contributor.author |
Karikas, A |
en |
| dc.contributor.author |
Constantinou-Kokotou, V |
en |
| dc.contributor.author |
Magrioti, V |
en |
| dc.contributor.author |
Kokotos, G |
en |
| dc.date.accessioned |
2014-06-06T06:44:21Z |
|
| dc.date.available |
2014-06-06T06:44:21Z |
|
| dc.date.issued |
2000 |
en |
| dc.identifier.issn |
10826076 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1081/JLC-100100457 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/1821 |
|
| dc.subject.other |
1,2 hexadecanediol |
en |
| dc.subject.other |
2 tetradecyl 1,4 butanediol |
en |
| dc.subject.other |
antineoplastic agent |
en |
| dc.subject.other |
busulfan |
en |
| dc.subject.other |
DNA |
en |
| dc.subject.other |
melphalan |
en |
| dc.subject.other |
sulfonic acid derivative |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
antineoplastic activity |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
cross linking |
en |
| dc.subject.other |
drug DNA interaction |
en |
| dc.subject.other |
drug potency |
en |
| dc.subject.other |
drug structure |
en |
| dc.subject.other |
drug synthesis |
en |
| dc.subject.other |
high performance liquid chromatography |
en |
| dc.title |
Study of DNA interactions with melphalan, busulphan, and analogues using an HPLC method |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1081/JLC-100100457 |
en |
| heal.publicationDate |
2000 |
en |
| heal.abstract |
A simple reversed phase HPLC method suitable to study the interactions of alkylating agents with DNA is presented in this paper. DNA interaction is expressed as the % DNA peak size exclusion. The effects caused by the antitumor drugs melphalan, busulphan, and busulpan analogues on DNA were clearly observed through chromatographic data. The synthetic dimethane-sulphonates of 2-tetradecyl-l,4-butanediol and 1,2-hexadecanediol were proved more potent than busulphan. |
en |
| heal.journalName |
Journal of Liquid Chromatography and Related Technologies |
en |
| dc.identifier.issue |
12 |
en |
| dc.identifier.volume |
23 |
en |
| dc.identifier.doi |
10.1081/JLC-100100457 |
en |
| dc.identifier.spage |
1859 |
en |
| dc.identifier.epage |
1864 |
en |