| dc.contributor.author |
Kokotos, G |
en |
| dc.contributor.author |
Kotsovolou, S |
en |
| dc.contributor.author |
Constantinou-Kokotou, V |
en |
| dc.contributor.author |
Wu, G |
en |
| dc.contributor.author |
Olivecrona, G |
en |
| dc.date.accessioned |
2014-06-06T06:44:19Z |
|
| dc.date.available |
2014-06-06T06:44:19Z |
|
| dc.date.issued |
2000 |
en |
| dc.identifier.issn |
0960894X |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/1802 |
|
| dc.relation.uri |
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034684754&partnerID=40&md5=8c48f12366fa68b183b3a7ed424f5497 |
en |
| dc.subject.other |
alkanesulfonic acid |
en |
| dc.subject.other |
fluoride |
en |
| dc.subject.other |
lipoprotein lipase |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
chemical reaction |
en |
| dc.subject.other |
drug inhibition |
en |
| dc.subject.other |
enzyme active site |
en |
| dc.subject.other |
enzyme activity |
en |
| dc.subject.other |
enzyme inhibition |
en |
| dc.subject.other |
extracellular matrix |
en |
| dc.subject.other |
lipoprotein blood level |
en |
| dc.subject.other |
receptor binding |
en |
| dc.subject.other |
solubility |
en |
| dc.subject.other |
synthesis |
en |
| dc.subject.other |
Alkanesulfonates |
en |
| dc.subject.other |
Animals |
en |
| dc.subject.other |
Cattle |
en |
| dc.subject.other |
Dose-Response Relationship, Drug |
en |
| dc.subject.other |
Enzyme Inhibitors |
en |
| dc.subject.other |
Inhibitory Concentration 50 |
en |
| dc.subject.other |
Kinetics |
en |
| dc.subject.other |
Lipids |
en |
| dc.subject.other |
Lipoprotein Lipase |
en |
| dc.subject.other |
Solubility |
en |
| dc.subject.other |
Structure-Activity Relationship |
en |
| dc.subject.other |
Sulfinic Acids |
en |
| dc.title |
Inhibition of lipoprotein lipase by alkanesulfonyl fluorides |
en |
| heal.type |
journalArticle |
en |
| heal.publicationDate |
2000 |
en |
| heal.abstract |
A number of alkanesulfonyl halides (chlorides and fluorides) and esters were synthesized and their effect on the activity of lipoprotein lipase (LPL) was studied. Sulfonyl fluorides proved to be efficient inhibitors of LPL when the enzyme was incubated with a 10-fold molar excess of the inhibitors in a buffer containing bile salts (deoxycholate). Hexadecane- and dodecanesulfonyl fluorides caused 50% inhibition of LPL activity at concentrations of 10 to 20 μM. (C) 2000 Elsevier Science Ltd. |
en |
| heal.journalName |
Bioorganic and Medicinal Chemistry Letters |
en |
| dc.identifier.issue |
24 |
en |
| dc.identifier.volume |
10 |
en |
| dc.identifier.spage |
2803 |
en |
| dc.identifier.epage |
2806 |
en |