| dc.contributor.author |
Couladouros, EA |
en |
| dc.contributor.author |
Moutsos, VI |
en |
| dc.date.accessioned |
2014-06-06T06:43:55Z |
|
| dc.date.available |
2014-06-06T06:43:55Z |
|
| dc.date.issued |
1999 |
en |
| dc.identifier.issn |
00404039 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1016/S0040-4039(99)01430-6 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/1550 |
|
| dc.subject |
Aromatic bromination |
en |
| dc.subject |
Bastadins |
en |
| dc.subject |
Iodonium salt |
en |
| dc.subject |
Natural products |
en |
| dc.subject |
Synthesis |
en |
| dc.subject.other |
alpha amino acid |
en |
| dc.subject.other |
bastadin 10 |
en |
| dc.subject.other |
bastadin 11 |
en |
| dc.subject.other |
bastadin 12 |
en |
| dc.subject.other |
bastadin 14 |
en |
| dc.subject.other |
bastadin 15 |
en |
| dc.subject.other |
bastadin 16 |
en |
| dc.subject.other |
bastadin 4 |
en |
| dc.subject.other |
bastadin 5 |
en |
| dc.subject.other |
bastadin 6 |
en |
| dc.subject.other |
bastadin 7 |
en |
| dc.subject.other |
bastadin 8 |
en |
| dc.subject.other |
bastadin 9 |
en |
| dc.subject.other |
bromine |
en |
| dc.subject.other |
iodine derivative |
en |
| dc.subject.other |
macrocyclic compound |
en |
| dc.subject.other |
natural product |
en |
| dc.subject.other |
omega amino acid |
en |
| dc.subject.other |
unclassified drug |
en |
| dc.subject.other |
article |
en |
| dc.subject.other |
bromination |
en |
| dc.subject.other |
cyclization |
en |
| dc.subject.other |
drug synthesis |
en |
| dc.subject.other |
iodination |
en |
| dc.subject.other |
partial drug synthesis |
en |
| dc.title |
A general synthetic route towards bastadins. Part 2: Synthesis of the western part of bastadins 4-16, and fully functionalized macrocycle of bastadin 12 |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1016/S0040-4039(99)01430-6 |
en |
| heal.publicationDate |
1999 |
en |
| heal.abstract |
A general synthetic route for the construction of the western part of the macrocyclic bastadins 4-16 is presented. The western and the eastern segments were coupled using the imidazolide of the corresponding acid. The bromine at position Y2 may be added at this advanced step regiospecifically, strengthening the convergence of the presented approach. Finally, the fully functionalized α,ω-aminoacid is cyclized with EDC affording the macrocyclic ring of bastadin-12 in 72% yield (3.5% overall yield). |
en |
| heal.journalName |
Tetrahedron Letters |
en |
| dc.identifier.issue |
38 |
en |
| dc.identifier.volume |
40 |
en |
| dc.identifier.doi |
10.1016/S0040-4039(99)01430-6 |
en |
| dc.identifier.spage |
7027 |
en |
| dc.identifier.epage |
7030 |
en |