| dc.contributor.author |
Papanastasiou, D |
en |
| dc.contributor.author |
Mamalaki, A |
en |
| dc.contributor.author |
Eliopoulos, E |
en |
| dc.contributor.author |
Poulas, K |
en |
| dc.contributor.author |
Liolitsas, C |
en |
| dc.contributor.author |
Tzartos, S |
en |
| dc.date.accessioned |
2014-06-06T06:43:52Z |
|
| dc.date.available |
2014-06-06T06:43:52Z |
|
| dc.date.issued |
1999 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1016/S0165-5728(98)00249-5 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/1516 |
|
| dc.subject |
Acetylcholine Receptor |
en |
| dc.subject |
Binding Affinity |
en |
| dc.subject |
Molecular Modeling |
en |
| dc.subject |
Muscle Cell |
en |
| dc.subject |
myasthenia gravis |
en |
| dc.subject |
Nicotinic Acetylcholine Receptor |
en |
| dc.subject |
Polymerase Chain Reaction |
en |
| dc.subject |
Amino Acid |
en |
| dc.subject |
Full Length |
en |
| dc.subject |
Immunoglobulin |
en |
| dc.subject |
Single Chain |
en |
| dc.title |
Construction and characterization of a humanized single chain Fv antibody fragment against the main immunogenic region of the acetylcholine receptor |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1016/S0165-5728(98)00249-5 |
en |
| heal.publicationDate |
1999 |
en |
| heal.abstract |
The single chain Fv fragment of mAb198 (scFv198) directed against the main immunogenic region (MIR) of the nicotinic acetylcholine receptor (AChR), can efficiently protect the AChR in muscle cell cultures against the destructive activity of human myasthenic autoantibodies. Humanization of the scFv198 antibody fragment should prove useful for therapeutic application by reducing its immunogenicity. Framework sequences from human immunoglobulins homologous |
en |
| heal.journalName |
Journal of Neuroimmunology |
en |
| dc.identifier.doi |
10.1016/S0165-5728(98)00249-5 |
en |