| dc.contributor.author |
Gorgoulis, V |
en |
| dc.contributor.author |
Zacharatos, P |
en |
| dc.contributor.author |
Manolis, E |
en |
| dc.contributor.author |
Ikonomopoulos, J |
en |
| dc.contributor.author |
Damalas, A |
en |
| dc.contributor.author |
Lamprinopoulos, C |
en |
| dc.contributor.author |
Rassidakis, G |
en |
| dc.contributor.author |
Zoumpourlis, V |
en |
| dc.contributor.author |
Kotsinas, A |
en |
| dc.contributor.author |
Rassidakis, A |
en |
| dc.contributor.author |
Halazonetis, T |
en |
| dc.contributor.author |
Kittas, C |
en |
| dc.date.accessioned |
2014-06-06T06:43:31Z |
|
| dc.date.available |
2014-06-06T06:43:31Z |
|
| dc.date.issued |
1998 |
en |
| dc.identifier.uri |
http://dx.doi.org/10.1038/bjc.1998.60 |
en |
| dc.identifier.uri |
http://62.217.125.90/xmlui/handle/123456789/1337 |
|
| dc.subject |
Amino Acid Substitution |
en |
| dc.subject |
Cell Line |
en |
| dc.subject |
Dna Binding |
en |
| dc.subject |
Feedback Loop |
en |
| dc.subject |
Lung Carcinoma |
en |
| dc.subject |
Non Small Cell Lung Carcinoma |
en |
| dc.subject |
Reporter Gene |
en |
| dc.subject |
Wild Type |
en |
| dc.title |
Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene |
en |
| heal.type |
journalArticle |
en |
| heal.identifier.primary |
10.1038/bjc.1998.60 |
en |
| heal.publicationDate |
1998 |
en |
| heal.abstract |
The present study represents a continuation of previous works in which we observed that lung carcinomas co-expressing MDM2 protein and p53 mutants (mt p53) exhibited more aggressive behaviour. In the above studies, we suggested a 'gain of function' mechanism of mt p53 proteins based on the fact that the MDM2 gene possesses a p53-responsive element (MDM2-p53RE). In this study, to |
en |
| heal.journalName |
British Journal of Cancer |
en |
| dc.identifier.doi |
10.1038/bjc.1998.60 |
en |