Synthesis and in vitro cytotoxicity of lipidic alcohols and amines

dc.contributor.author	Constantinou-Kokotou, V	en
dc.contributor.author	Kokotos, G	en
dc.contributor.author	Roussakis, C	en
dc.date.accessioned	2014-06-06T06:43:29Z
dc.date.available	2014-06-06T06:43:29Z
dc.date.issued	1998	en
dc.identifier.issn	02507005	en
dc.identifier.uri	http://62.217.125.90/xmlui/handle/123456789/1311
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0031731154&partnerID=40&md5=0f2f2af2781b047212e539a0213ca6e0	en
dc.subject	Cytotoxicity	en
dc.subject	Lipidic alcohols	en
dc.subject	Lipidic amines	en
dc.subject	Synthesis	en
dc.subject.other	alcohol derivative	en
dc.subject.other	diamine derivative	en
dc.subject.other	lipid	en
dc.subject.other	animal cell	en
dc.subject.other	article	en
dc.subject.other	controlled study	en
dc.subject.other	drug cytotoxicity	en
dc.subject.other	drug synthesis	en
dc.subject.other	mouse	en
dc.subject.other	nonhuman	en
dc.subject.other	priority journal	en
dc.subject.other	Amino Alcohols	en
dc.subject.other	Animals	en
dc.subject.other	Drug Screening Assays, Antitumor	en
dc.subject.other	Fatty Alcohols	en
dc.subject.other	Inhibitory Concentration 50	en
dc.subject.other	Leukemia P388	en
dc.subject.other	Tumor Cells, Cultured	en
dc.title	Synthesis and in vitro cytotoxicity of lipidic alcohols and amines	en
heal.type	journalArticle	en
heal.publicationDate	1998	en
heal.abstract	General methods for the conversion of unsaturated fatty acids into alcohols and amines and the preparation of lipidic 1,2-diamines were developed. The in vitro cytotoxicity of the synthetic lipidic compounds was tested against two different cell lines (P388 and NSCLCN6). Oleyl amine was the most active among the lipidic alcohols and monoamines. However, the saturated lipidic 1,2-hexadecanediamine exhibited the highest cytotoxicity (IC50 0.1 μg/ml and 1.1 μg/ml).	en
heal.journalName	Anticancer Research	en
dc.identifier.issue	5 A	en
dc.identifier.volume	18	en
dc.identifier.spage	3439	en
dc.identifier.epage	3442	en